The GRIN2B gene encodes a subunit of the NMDA receptor, a crucial protein complex in the brain that enables learning, memory formation, and healthy brain development. Mutations in this gene can disrupt NMDA receptor function, leading to GRIN2B-Related Neurodevelopmental Disorder, a condition that can significantly impact cognitive, motor, and communication abilities, often requiring lifelong support. Importantly, GRIN2B is also implicated in broader neurological conditions such as Autism Spectrum Disorder, Epilepsy, and Alzheimer’s Disease. Advancing research into GRIN2B not only brings hope to affected families but also holds potential benefits for millions across these larger communities.