Join us on the path to curing GRIN2B Related Neurodevelopmental Disorder

2BCured is a partnership between parents and trailblazing experts committed to finding a cure and improving treatment options for GRIN2B Related Neurodevelopmental Disorder.

We're halfway to our goal of raising $8 million to support the next 5 years of research.

Impact of GRIN2B disorder

The GRIN2B gene encodes receptors in the brain that are critical to learning and forming memories. Mutations in this gene can result in GRIN2B Related Neurodevelopmental Disorder. This devastating condition can render children completely dependent on their caregivers.

Common symptoms of GRIN2B disorder

Intellectual disability
Non-verbal and/or limited speech and communication abilities
Drug-resistant seizures
Features of Autism Spectrum Disorder and other conditions such as ADHD and schizophrenia
Gross and fine motor delays and disabilities
Gastrointestinal problems
Muscle tone abnormalities (spasticity and/or hypotonia)

There is currently no cure for GRIN2B Related Neurodevelopmental Disorder.

We're working to change that.

Meet Maisie

After a smooth delivery, Maisie faced breathing problems, low oxygen levels, and seizures, requiring six months in Neonatal Intensive Care. Genetic testing revealed a GRIN2B gene mutation. At three years old, she's profoundly affected by GRIN2B Disorder, with severely limited mobility, vision impairment, a feeding tube, and drug-resistant epilepsy. Like many with the disorder, Maisie is entirely dependent on her caregivers.